University | Catalogues for 2005/06 | for UGs | for PGs

Credits: 0

Level: Certificate

Academic Year

Assessment: CW100

Requisites:

Aims: To develop methodologies for solving quantitative problems in Chemistry.
Learning Outcomes:
After studying this unit, students should be able to:
* Understand basic concepts of magnitudes and units in the context of chemistry.
* Identify the steps needed to formulate problems in different areas of chemistry in a quantitative way.
* Apply basic mathematical skills including analytical and graphical methods to the solution of properly formulated problems.
* Use a spreadsheet such as Excel to handle and visualize data and calculations in Chemistry.
Skills:
Numeracy (F, A), Problem solving (T, F, A).
Content:
* Basic quantitative concepts in analytical chemistry
* Basic quantitative concepts in structural chemistry
* Basic quantitative concepts in thermodynamics
* Basic quantitative concepts in spectroscopy
* Basic quantitative concepts in kinetics
* Basic quantitative concepts in surface chemistry.

CH20013: Characterisation methods

Credits: 6

Level: Intermediate

Semester: 1

Assessment: EX100

Requisites:

Before taking this unit you must take CH10089 and take CH10090 and take CH20015

Aims & Learning Objectives:
To provide an introduction to a number of techniques for characterisation of chemical compounds, including an introduction to Group Theory and its applications in interpreting the spectra and structures of inorganic compounds. After studying this Unit, students should be able to:
* Describe the principles underlying the techniques studied.
* Interpret and make calculations based on simple X-ray diffraction patterns.
* Interpret and predict NMR spectra for a range of nuclei other than ¹H , ¹³C.
* Interpret and predict ESR spectra. - Identify symmetry elements in and define the point group of a molecule. - Fully assign the vibrational spectra (IR and Raman) using Group Theory.
* Use Group Theory to draw MO diagrams for simple chemical species.
Content:
Overview of X-ray generation and use of filters. Crystal classes, lattices and unit cells. Bragg's Law. Uses of powder diffraction. General principles of NMR - magnetic properties of nuclei, sensitivity and abundance. Spectra with I>1/2 nuclei. Chemical shifts and coupling constants. Problems with I> 1/2 nuclei. Magnetic properties of the electron and the origin and interpretation of ESR spectra. The concept of symmetry and symmetry operations and their use to generate point groups for molecular species. Group Theory and vibrational spectoscopy.

CH20014: Synthesis of organic molecules

Credits: 6

Level: Intermediate

Semester: 1

Assessment: EX80CW20

Requisites:

In taking this unit you cannot take CH20078 and before taking this unit you must take CH10090

Aims & Learning Objectives:
To provide the student with a working knowledge of important classes of organic transformations, including mechanisms. To give an overview of retrosynthetic analysis as a valuable method for the design of an organic molecule. After studying this Unit, students should be able to:
* interpret and predict NMR spectra and mass spectra;
* account for the importance of stereoselectivity in organic synthesis;
* demonstrate the important relationship between structure and reactivity for organic molecules;
* design syntheses of heterocyclic and alicyclic compounds from common starting materials;
* apply retrosynthesis methods to a selected range of compounds.
Content:
Interpretation of NMR spectra including homotopic and diastereotopic protons. Correlation spectroscopy. Mass spectrometry. The principles of retrosynthesis. The use of carbon nucleophiles in retrosynthesis. Malonate ester synthesis and applications. Umpolung reagents. Alkene synthesis, including Wittig reaction. Oxidation reactions of alkenes and alcohols. Reduction reactions of ketones and other carbonyl compounds. Review of aromatic chemistry. Description, reactivity and synthesis of heterocycles including pyrroles, furan, thiophene, pyridine and indoles. Synthesis and reactivity of naphthalene, quinolines and isoquinolines. Concepts of organopalladium chemistry. Concepts of combinatorial chemistry for the synthesis of libraries of heterocycles.

CH20015: Transition metal chemistry

Credits: 6

Level: Intermediate

Semester: 1

Assessment: EX80CW20

Requisites:

In taking this unit you cannot take CH20079 and before taking this unit you must take CH10007 or take CH10089

Aims & Learning Objectives:
To provide an introduction to the chemistry of transition metal elements and the theories underlying their behaviour. After studying this Unit, students should be able to:
* Describe bonding models that can be applied to a consideration of the properties of transition metal compounds.
* Account for the solution chemistry of representative elements as a guide to the reactivity of the transition metals.
* Appreciate the chemistry of transition metal compounds containing metal-carbon s- and p-bonds.
Content:
General properties of transition metal compounds. Crystal field theory and ligand field theory. Descriptive chemistry of first row transition metal elements (e.g. V,Fe,Ni). Organometallics - nomenclature, electron counting. Metal-carbon s- and p-bonding.

CH20016: Interfacial chemistry

Credits: 6

Level: Intermediate

Semester: 2

Assessment: EX80TE20

Requisites:

Before taking this unit you must take CH10090

Aims & Learning Objectives:
To provide an introduction to the physical chemistry of interfaces and to demonstrate its significance in catalysis and colloid science. After studying this units, students should be able to:
* Describe and define the types of adsorption at solid surfaces
* Explain the qualitative and quantitative basis of catalysis and physical adsorption
* Define surface tension and solve simple problems involving its application
* Define and interpret the forces between two colloids
* Describe the different processes which control reactions at solid/liquid interfaces.
Content:
Introduction to surfaces. Chemisorption versus physisorption. Adsorbed amounts. Types of isotherms: Langmuir Isotherm. Determination of heat of adsorption, BET isotherm: Introduction to heterogeneous catalysis. Kinetics of catalysis. Langmuir Hinshelwood mechanism. Eley Rideal mechanism. Catalysis examples Modern surface science techniques. Molecular basis and consequences of surface tension. Colloid stability. Micellisation. Gibbs equation. Reactions at solid/liquid interfaces. Mass transport, surface reactivity.

CH20017: Organic reaction mechanisms

Credits: 6

Level: Intermediate

Semester: 2

Assessment: EX80CW20

Requisites:

Before taking this unit you must take CH20014 or take CH20078

Aims & Learning Objectives:
To illustrate how the rate and mechanism of a chemical reaction can be understood in terms of the chemical structure of molecules. After studying this Unit, students should be able to:
* Describe the synthetic chemistry of carbocations, anions and radical species and describe some of the mechanisms involved in their reaction.
* Describe some experimental methods for investigating reaction rate and mechanism.
* Account for the temperature dependence of reaction rates.
* Define the stereochemical implications of a range of common mechanisms.
* Summarise how the mechanism of a reaction may be found from structural and kinetic data.
* Rationalise the reactivity of molecules using stereoelectronic principles.
Content:
Evidence for mechanisms and intermediates; principles for acceptability;. Solvent and substituent effects on equilibria. Rates for reactions of various kinetic orders, and kinetic treatment of more complex mechanisms. Theoretical treatments of reaction kinetics and examples of their application. Reactions in solution. Catalysis by acids and bases.; Nucleophilic catalysis. Review of basic stereochemistry principles. The importance of stereoselective synthesis. Diastereomers and diastereoselective synthesis. Conformation of cyclohexanes - the importance of stereochemistry to reactivity - carbohydrates. Stereochemistry and mechanism. Frontier Molecular Orbital Theory and stereoelectronic effects. Aspects of the chemistry of carbocations, carbanions, radicals, carbenes, nitrenes, and arynes.

CH20020: Inorganic chemistry laboratory 2

Credits: 3

Level: Intermediate

Semester: 1

Assessment: PR100

Requisites:

While taking this unit you must take CH20015 and take CH20021 and take CH20022 and take CH20023 and before taking this unit you must take CH10010 and in taking this unit you cannot take CH20024 or take CH20025

Only available to students on Chemistry programmes.
Aims & Learning Objectives:
To provide experience in synthetic inorganic chemistry and introduce a range of experimental techniques and to give students the experience of presenting scientific results by means of a poster presentation.
After studying this Unit, students should be able to:
* Perform straightforward syntheses of coordination and organometallic compounds.
* Analyse compounds using a range of physical methods.
* Deduce structural information from physical methods of analysis.
* Write a clear and concise account of the experimental work undertaken and the deductions made from it.
* Prepare and present a poster on a chemical topic.
Content:
The experiments have been designed to illustrate some of the important features of coordination and organometallic chemistry. Compounds will be prepared and information obtained from a number of physical methods including IR spectroscopy, NMR, UV/visible spectroscopy, atomic absorption and measurement of magnetic moment. Experiments illustrating specific techniques such as column chromatography and inert atmosphere chemistry will also be performed.

Credits: 3

Level: Intermediate

Semester: 1

Assessment: PR100

Requisites:

Before taking this unit you must take CH10009 and take CH10010 and in taking this unit you cannot take CH20020 or take CH20023

Aims & Learning Objectives:
Two aspects of practical chemistry will be introduced in this Unit. It aims to demonstrate the utility of synthetic inorganic chemistry and the use of computational packages for molecular modelling as tools for the solution of chemical problems In addition, the students will experience the presentation of scientific results in the form of a poster.
After studying this Unit, students should be able to:
* Build and manipulate computational molecular models to assist interpretation of chemical structue, bonding and properties.
* Use computer packages to perform calculations to opitimise molecular geometry, determine atomic charges and electrostatic potentials, display molecular orbitals and normal modes of vibration.
* Perform straightforward syntheses of coordination and organometallic compounds.
* Analyse compounds using a number of physical methods.
* Deduce structural information from physical methods of analysis.
* Prepare and present a poster on a scientific topic.
Content:
Experiments designed to illustrate the important features of metal d-block chemistry coordination chemistry, organometallics and metal-metal bonded compounds. Interpretation of spectra. Molecular mechanics with SPARTAN: conformations of six-membered rings. Molecular orbital calculations with SPARTAN: qualitative MO theory and molecular vibrations; conjugation and colour. Introduction to Beilstein and Gmelin electronic databases.

CH20025: Physical & organic chemistry laboratory

Credits: 3

Level: Intermediate

Semester: 2

Assessment: PR100

Requisites:

Before taking this unit you must take CH10011 and take CH10012 and in taking this unit you cannot take CH20020 or take CH20023

This unit is only available to students on Chemistry with Management programmes.
Aims & Learning Objectives:
To build on existing practical chemistry techniques and reinforce lecture material. To provide the necessary key skills for the preparation and delivery of a short presentation based on an organic chemistry experiment.
After studying this unit, students should be able to:
* Use spreadsheets to analyse data in a competent manner.
* Understand the importance of experimental design and safety
* Evaluate complicated results in terms of the theory underlying the experiment
* Write coherent scientific reports on obtained data
* To interpret spectroscopic data of a wide variety and to relate this to the spatial, structural and chemical features of the compounds synthesised in the laboratory.
* To apply their experience in synthetic organic chemistry to other organic reactions.
* To demonstrate their practical skills and techniques to a good level of ability.
* To give an oral presentation based on an experiment performed in the laboratory.
Content:
Experiments involving surface analysis, colloid science, and reaction kinetics requiring computer based analysis of results. Synthesis of organic compounds and interpretation of information obtained from physical methods.

CH20078: Organic synthesis and spectroscopy (NS)

Credits: 6

Level: Intermediate

Semester: 1

Assessment: CW20PR10EX70

Requisites:

In taking this unit you cannot take CH20014

Only available to students on Natural Science programmes.
Aims & Learning Objectives:
To provide the student with a working knowledge of important classes of organic transformations, including mechanisms. To give an overview of retrosynthetic analysis as a valuable method for the design of an organic molecule. After studying this Unit, students should be able to:
* interpret and predict NMR spectra and mass spectra;
* account for the importance of stereoselectivity in organic synthesis;
* demonstrate the important relationship between structure and reactivity for organic molecules;
* perform straightforward synthetic and analytical procedures in the laboratory;
* design syntheses of heterocyclic and alicyclic compounds from common starting materials;
* apply retrosynthesis methods to a selected range of compounds.
Content:
Interpretation of NMR spectra including homotopic and diastereotopic protons. Correlation spectroscopy. Mass spectrometry. The principles of retrosynthesis. The use of carbon nucleophiles in retrosynthesis. Malonate ester synthesis and applications. Umpolung reagents. Alkene synthesis, including Wittig reaction. Oxidation reactions of alkenes and alcohols. Reduction reactions of ketones and other carbonyl compounds. Review of aromatic chemistry. Description, reactivity and synthesis of heterocycles including pyrroles, furan, thiophene, pyridine and indoles. Synthesis and reactivity of naphthalene, quinolines and isoquinolines. Concepts of organopalladium chemistry. Concepts of combinatorial chemistry for the synthesis of libraries of heterocycles.

CH20079: Transition metal chemistry (NS)

Credits: 6

Level: Intermediate

Semester: 1

Assessment: CW20PR10EX70

Requisites:

Before taking this unit you must take CH10007 or (take CH10089 and in taking this unit you cannot take CH20015

Only available to students on Natural Science programmes.
Aims & Learning Objectives:
To provide an introduction to the chemistry of transition metal elements and the theories underlying their behaviour. After studying this Unit, students should be able to:
* Describe bonding models that can be applied to a consideration of the properties of transition metal compounds.
* Account for the solution chemistry of representative elements as a guide to the reactivity of the transition metals.
* Perform straightforward synthetic and analytical procedures in the laboratory.
* Appreciate the chemistry of transition metal compounds containing metal-carbon s- and p-bonds.
Content:
General properties of transition metal compounds. Crystal field theory and ligand field theory. Descriptive chemistry of first row transition metal elements (eg V,Fe,Ni). Organometallics - nomenclature, electron counting. Metal carbon s and pbonding.

CH20095: Main group and environmental chemistry

Credits: 6

Level: Intermediate

Semester: 2

Assessment: CW20EX80

Requisites:

Before taking this unit you must take CH10005 and take CH10090

Aims: The unit will provide an introduction to synthesis of the elements, and discuss specific aspects of radio- and nuclear-chemistry and their applications. The unit will also introduce the topic of main group organometallic chemistry. Selected aspects of main group chemistry from the first year (CH10005) will also be built upon with particular reference to the heavier p-block elements. An introduction to selected aspects of environmental chemistry will also be given.
Learning Outcomes:
After studying the unit, students should be able to:
* Describe the genesis of the elements and selected nuclear properties, such as factors affecting nuclear stability and outline-selected applications of radioactive decay processes.
* Describe the synthesis, structure, bonding and applications of selected organo s- and p-block compounds.
* Describe the properties and factors effecting stability and reactivity of heavy p-block containing compounds
* Describe the chemistry behind important environmental problems such as global warming and ozone depletion.
Skills:
Numeracy (F, A), Problem solving (T, F, A), Scientific writing (F, A), Independent working (F), Group working (F).
Content:
The genesis of the elements. The nature, properties and applications of radioactivity and radioactive elements. The nature and properties of selected p-block element containing compounds (Inter halogen complexes, cationic/anionic Halogen and Chalcogen systems). Chemistry of the Noble gases. The role of d-orbitals in main group element bonding (3-centre 4-electron bonding Vs d-orbital participation). P-block ring systems (BN, SN, SeN and PN). Classification of organometallics, general aspects of stability structure and bonding The History, synthesis, structure, bonding and reactivity of main group organometallics (e.g. organolithiums, oragnomagnesiums and organoaluminiums). The application of selected of main group organometallic compounds. Atmospheric chemistry and the roles of N, O and halogens in relation to ozone producing cycles and organic radicals. The Greenhouse effect.

CH20096: Quantum mechanics and spectroscopy

Credits: 6

Level: Intermediate

Semester: 2

Assessment: CW20EX80

Requisites:

Before taking this unit you must take CH10090 and take CH10094

Aims: The Unit will describe the physical basis of spectroscopy, developing from the basic quantum mechanics of simple molecules to the interpretation of spectra of complex molecules.
Learning Outcomes:
After studying this Unit, students should be able to:
* Define the terms 'wavefunction' and 'eigenvalue'.
* Relate physical models to quantisation of molecular and electronic energies.
* Use quantum mechanical methods to generate and rationalise the structure and bonding in organic molecules.
* Predict the pure rotation and vibration-rotation spectra of linear diatomic molecules.
* Describe the fundamental processes that lead to absorption, emission and scattering of electromagnetic radiation from molecular species, and interpret IR and Raman spectra.
Skills:
Numeracy (F, A), Problem solving (T, F, A) Scientific writing (F, A), Independent working (F) Group working (F)
Content:
Basic principles of quantum mechanics; wavefunctions, eigenvalues and operators. Solving the Schrödinger equation and the calculation of energy levels. Development of the variation method applied to diatomic molecules and hydrocarbons. Calculation of electronic and bonding energies. The relationship between molecular orbitals, electron density and reactivity. Introduction to electromagnetic radiation. Rotational spectroscopy; rigid rotor model. Vibrational spectroscopy. Linear diatomic and polyatomic molecules. Vibration-rotation spectroscopy. IR vibrational spectra of complex molecules. Rotational and vibrational Raman spectroscopy. Electronic adsorption and emission processes. The fate of electronically excited states. Fluorescence and phosphorescence.

CH20097: Drug properties

Credits: 6

Level: Intermediate

Semester: 2

Assessment: CW20EX80

Requisites:

Before taking this unit you must take CH10089 and take CH10090 and take CH20014

Aims: The Unit will provide an introduction to the properties of drugs and some of the key aspects of medicinal chemistry which need to be considered by chemists involved in synthesising new drug molecules.
Learning Outcomes:
After studying the Unit, students should be able to:
* identify common features of drug molecules;
* illustrate the utility of 'log P' values and the importance of drug solubility;
* describe structure/activity relationships and understand how this aids the drug discovery process;
* provide examples of how drugs are able to interact with DNA/RNA/enzyme receptors;
* provide examples of drug metabolism.
Skills:
Numeracy (F, A); Problem solving (T, F, A); Scientific writing (F, A), Independent working (F); Group working (F).
Content:
Properties of drugs described by the Lapinski rules. Definition and use of log P and its relevance to bioavailability. Structure/activity relationships. Overview of successful drugs. Interactions of drug molecules with DNA and RNA. Case studies of enzyme inhibition and the mechanism of drug action. Natural products as drugs.

CH20126: Reaction kinetics and photochemistry

Credits: 6

Level: Intermediate

Semester: 1

Assessment: CW20EX80

Requisites:

Before taking this unit you must take CH10007 or take CH10090

Aims: To illustrate how the rate and mechanism of chemical reactions can be measured and understood to correlate molecular behaviour.
Learning Outcomes:
After studying this Unit, students should be able to:
* Describe some experimental methods for investigating reaction rate and mechanism and how kinetic parameters may be calculated.
* Account in kinetic terms for the mechanism of a range of reactions.
* Analyse kinetic data in terms of a number of theoretical models.
* Account for the effect of parameters such as temperature, pressure, concentration, ionic strength, solvent on reaction kinetics.
* Describe the effect of light on some chemical reactions and account for the rates of photochemical processes.
Skills:
Numeracy (F, A), Problem solving (T, F, A) Independent Working (F).
Content:
The Unit will describe the physical basis of spectroscopy, developing from the basic quantum mechanics of simple molecules to the interpretation of spectra of complex molecules. Revision of basics of reaction kinetics - order, molecularity, temperature effects. Kinetic treatment of more complex mechanisms such as chain and oscillating reactions, enzyme kinetics. Theoretical treatments of reaction kinetics and examples of their application. e.g. collision theory, transition state theory. Reactions in solution. Diffusion and activation control, the "cage" effect. Experimental methods for studying reactions: Basic photochemical methods and processes. Applications of photochemistry. Kinetics of photochemical reactions. New methods of studying reactions: molecular beams; reaction dynamics.

CH20142: Characterisation methods and organometallic chemistry

Credits: 6

Level: Intermediate

Semester: 1

Assessment: EX100

Requisites:

This unit is only available to students transferring from Year 2 at Exeter University.
Aims: To provide an introduction to NMR (other than ¹H and ¹³C), ESR, Group Theory and organotransition metal chemistry. The application of the characterisation techniques to the study of organtransition metal chemistry will be stressed.
Learning Outcomes:
After studying this Unit, students should be able to:
* Describe the principles underlining the techniques studied.
* Interpret and predict NMR spectra for a range of nuclei other than ¹H, ¹³C.
* Interpret and predict ESR spectra.
* Identify symmetry elements in and define the point group of a molecule
* Fully assign the vibrational spectra (IR and Raman) using Group Theory
* Use Group Theory to draw MO diagrams for simple chemical species
* Understand the basic chemistry of transition metal compounds containing metal-carbon σ- and π-bonds.
Skills:
Numeracy (F, A). Problem solving (T, F, A). Oral communication (F).
Content:
General principles of NMR - magnetic properties of nuclei, sensitivity and abundance. Spectra of I = 1/2 nuclei. Chemical shifts and coupling constants. Problems with I>1/2 nuclei. Magnetic properties of the electron and the origin and interpretation of ESR spectra. The concept of symmetry and symmetry operations and their use to generate point groups for molecular species. Group theory and vibrational spectroscopy. Organometallics - nomenclature, electron counting. Metal carbon σ and π bonding.

Credits: 6

Level: Honours

Semester: 1

Semester: 2

Assessment: RT60OR40

Requisites:

Before taking this unit you must take CH20020 and take CH20021 and take CH20022 and (take CH30033 or take CH20024) and take CH20025

Aims & Learning Objectives:
To introduce students to the skills necessary in retrieving information from a variety of Chemical Literature sources and preparation of an in-depth report on a topic. After studying the Unit, students should be able to
* Recognise and use appropriate text and electronic sources of chemical information
* Assemble information from a number of sources into a coherent report
* Prepare and deliver an oral presentation using appropriate visual aids
Content:
In conjunction with a supervisor, a topic of recent research or other chemical significance will be selected. Several key references will be identified and the student will use these as a basis to prepare a detailed, critical survey of the area. In addition to `paper' sources, computer based data retrieval systems will be used. Students will prepare a written report and also a short oral presentation on the selected topic.

CH30054: Industrial placement (BSc hons)

Credits: 60

Level: Honours

Academic Year

Assessment: RT100

Requisites:

In taking this unit you cannot take CH30058 and take CH30082 and take CH30084

Available for students on BSc sandwich courses in the Department of Chemistry. Will also be available to Natural Science students registered with the department.
Aims & Learning Objectives:
To provide students with an opportunity to gain a years experience of working in a chemical company or related organisation. The placement will allow students to:
* Apply knowledge and skills gained at University to real applications of Chemistry and related areas.
* Demonstrate a range of "key skills" such as team work, time and project management, oral and written communication.
* Participate in an extended programme of scientific work and develop professional skills appropriate to that area of work.
Content:
A laboratory or office based project with training programme will be conducted in a company or organisation approved by the Department of Chemistry. The content will depend on the precise requirements of the placement company.

CH30055: Industrial placement (MChem)

Credits: 42

Level: Honours

Academic Year

Assessment: OT100

Requisites:

While taking this unit you must take CH40062 and take CH40130 and in taking this unit you cannot take CH30060 or take CH30081 or take CH30083

Available only for students on M.Chem. with Industrial Training degree programme.
Aims & Learning Objectives:
To provide students with an opportunity to gain a years experience of working in a chemical company or related organisation. During the placement, students will be expected to:
* Apply knowledge and skills gained at University to real applications of Chemistry and related areas.
* Demonstrate a range of "key skills" such as team work, time and project management, oral and written communication.
* Participate in an extended programme of experimental work and develop practical skills appropriate to the area of work.
* Participate in discussions concerning their work and contribute ideas as appropriate.
* Prepare an oral presentation and a poster at appropriate times during the placement
Content:
A research project will be conducted in a company or organisation approved by the Department of Chemistry. The content will depend on the precise requirements of the placement.

CH30058: Study year abroad (BSc hons)

Credits: 60

Level: Honours

Academic Year

Assessment: RT100

Requisites:

In taking this unit you cannot take CH30054 or take CH30082 or take CH30084

Only available to students on BSc programmes with Study Year Abroad. Exceptionally, the unit may be available to students on BSc Natural Science.
Aims & Learning Objectives:
Students will gain experience of living and studying in a University outside the UK. They will have the opportunity to develop personal and linguistic skills in addition to developing their knowledge and understanding of chemistry and its applications. After studying this Unit, students should be able to:
* develop personal and interpersonal communication skills;
* demonstrate the ability to work and interact effectively in a group environment in which cultural norms and ways of operating may be unfamiliar;
* operate effectively with people from a different cultural background;
* (where appropriate) improve their knowledge of the host language by attending classes therein and interacting with native speakers.
Content:
The precise programme of study will normally involve an in depth research project, attendance at appropriate classes to support the research topic as well as other classes. The programme will vary considerably depending on the host University but will be agreed in advance with the Director of Studies.

CH30060: Study year abroad (MChem)

Credits: 42

Level: Honours

Academic Year

Assessment: OT100

Requisites:

In taking this unit you cannot take CH30055 or take CH30081 or take CH30083 and while taking this unit you must take CH40092 and take CH40130

Only available to students on M.Chem programmes with study year abroad.
Aims & Learning Objectives:
Students will gain experience of living and studying in a University outside the UK. They will have the opportunity to develop personal and linguistic skills in addition to developing their knowledge and understanding of chemistry and its applications. After studying this unit, students should be able to:
* develop personal and interpersonal communication skills;
* demonstrate the ability to work and interact effectively in a group environment in which cultural norms and ways of operating may be unfamiliar;
* operate effectively with people from a different cultural background;
* (where appropriate) improve their knowledge of the host language by attending classes therein and interacting with native speakers.
Content:
The precise programme of study will normally involve a high level chemical research project, attendance at appropriate classes to support the research topic as well as other classes. The programme will vary considerably depending on the host University but will be largely related to the chemical sciences and will be agreed in advance with the Director of Studies. The academic level of the programme will be at a similar level to those taken by Year 3 MChem students at Bath.

Credits: 3

Level: Honours

Semester: 1

Assessment: EX100

Requisites:

Aims & Learning Objectives:
This core unit will introduce the basic concepts needed to describe the synthesis and characterisation of a range of polymers in order to understand how their properties can be controlled. After studying the Unit, students should be able to:
* Demonstrate an understanding of how polymer structure can be influenced by the methods of synthesis and how this affects material properties.
* Describe and explain methods for synthesis by step- and chain growth polymerization
* Perform a range of numerical problems concerning polymerization chemistry
Content:
Classification and types of polymers. Synthesis of polymers with examples taken from several different classes (addition, step-growth, ring opening, organometallic) with the emphasis on how physicochemical considerations influence the polymer structure. Characterisation of polymers (molecular weight and chain length, spectroscopy, thermal methods). Structure and morphology of polymers and how this influences properties. Polymer solutions and thermodynamics of polymer mixtures. A survey of recent applications taken from current research and industrial topics.

CH30068: Physical organic chemistry

Credits: 3

Level: Honours

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20017 and in taking this unit you cannot take CH40068

Aims & Learning Objectives:
To revise some basic concepts in physical organic chemistry and develop a number of ideas used to correlate reactivity and mechanism in a range of organic reactions. After studying the Unit, students should be able to:
* Describe some experimental tools for investigating reaction mechanisms and the use of some theoretical models for their correlation and interpretation
* Solve a range of problems involving numerical and mechanistic information
Content:
Energy changes in equilibria and reactivity. Transition states and saddle points. Activation parameters. Analysis of reaction coordinates. Principle of Least Nuclear Motion. Hammond Postulate. More O'Ferrall - Jencks diagrams. Rate - equilibrium correlations. Hammett equation as an example of a linear free-energy relationship. Signficance of s and r for reactivity and mechanism. Complex Hammett plots : change in mechanism vs. change in rate-determining step. Equilibrium and kinetic isotope effects. Primary and secondary effects and their significance. Heavy-atom effects. Solvent isotope effects.

CH30070: Recent developments in organic chemistry

Credits: 3

Level: Honours

Semester: 1

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014

Aims & Learning Objectives:
This unit covers the concepts and ideas needed to understand modern stereoselective organic synthesis. After studying this unit students should be able to:
* Analyse the stereochemical course of a variety of reactions.
* Describe reagent systems to effect a wide range of simple transformations.
* Apply the information learned to solve new problems.
Content:
The unit begins with a section concerned with simple diastereoselection, focusing on the reactions of carbonyl and alkene systems. The concepts of allylic strain and directed reactions are introduced. The use of chiral auxiliaries to control the stereochemistry of organic reactions forms the second section. Particular systems studied include the use of SAMP and RAMP hydrazones and Evans' auxiliaries to control a range of chiral-enolate based bond constructions. The final selection of the unit focuses on the development and application of practical enantioselective catalysts of particular relevance to the fine chemical industry. Examples of transformations to be studied will include hydrogenation of double bonds, oxidations and carbon-carbon bond forming reactions.

CH30071: Organoelement chemistry

Credits: 3

Level: Honours

Semester: 1

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014 or take CH20078

Aims & Learning Objectives:
To describe some modern aspects of organic synthesis, including, the use of unconventional elements in synthesis. After studying this Unit, students should be able to:
* Appreciate why organoelement chemistry is used in synthesis.
* Describe a wide range of new synthetic transformations.
* Describe fully the mechanism of these reactions.
* Apply the information learnt to solve new problems.
Content:
Organoboron chemistry. Organosilicon chemistry. Organophosphorus chemistry. Organosulphur chemistry. Organometallics in Organic Synthesis. Carbonylation reactions. Coupling reactions. Methods of C-C bond formation.

CH30072: Main group ring systems

Credits: 3

Level: Honours

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20095 and in taking this unit you cannot take CH40072

Aims & Learning Objectives:
To consider the synthesis, structure, bonding and uses of main group ring compounds with particular emphasis on the transition from ionic to covalent systems. After studying the Unit, students should be able to:
* Explain the solid state and solution structures of a range of main group ring compounds (i.e. those containing Li, Mg, Al, B, Si, P and S)
* Describe how these compounds are synthesised and how their structure and bonding varies
* Describe some uses of these compounds
* Interpret analytical data (e.g. NMR) in order to elucidate structures
Content:
The structure, bonding and synthesis of organolithium ring systems. A detailed examination of lithium amide and imide structures leading to a general theory of ring stacking and laddering. Comparison of Li, Mg and Al ring systems. A survey of the synthesis, structure and bonding of B-N, Si-N, P-N and S-N ring systems.

CH30074: Photochemistry

Credits: 3

Level: Honours

Semester: 1

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014

Aims & Learning Objectives:
To revise the basic principles of photo chemistry taught in previous units and to introduce techniques for the study of and applications of photochemistry. After studying the Unit, students should be able to:
* Account for the formation and decay of electronically excited states in molecules
* Describe modern instrumental methods for photochemical investigation
* Solve a range of quantitative problems in these topics.
Content:
Absorption and emission of light. Jablonskii scheme. Excited state kinetics and quenching. Experimental methods. Properties and reactions of excited states. Examples of photochemical processes including photosynthesis, photography, solar energy conversion and atmospheric photochemistry.

CH30081: Industrial placement (MChem - half year)

Credits: 21

Level: Honours

Academic Year

Assessment: OT100

Requisites:

While taking this unit you must take CH30083 and take CH40092 and take CH40130 and in taking this unit you cannot take CH30055 or take CH30060

Aims & Learning Objectives:
To provide students with an opportunity to gain experience of working in a chemical company or related organisation. During the placement, students will be expected to:
* Apply knowledge and skills gained at University to real applications of Chemistry and related areas.
* Demonstrate a range of "key skills" such as team work, time and project management, oral and written communication.
* Participate in an extended programme of experimental work and develop practical skills appropriate to the area of work.
* Participate in discussions concerning their work and contribute ideas as appropriate.
Content:
A research project will be conducted in a company or organisation approved by the Department of Chemistry. The content will depend on the precise requirements of the placement.

CH30082: Industrial placement (BSc - half year)

Credits: 30

Level: Honours

Academic Year

Assessment: RT100

Requisites:

While taking this unit you must take CH30084 and in taking this unit you cannot take CH30054 or take CH30058

Available for students on BSc sandwich courses in the Department of Chemistry. Will also be available to Natural Sciences students registered with the Department.
Aims & Learning Objectives:
To provide students with an opportunity to gain experience of working in a chemical company or related organisation. The placement will allow students to:
* Apply knowledge and skills gained at University to real applications of Chemistry and related areas.
* Demonstrate a range of "key skills" such as team work, time and project management, oral and written communication.
* Participate in an extended programme of scientific work and develop professional skills appropriate to that area of work.
Content:
A laboratory or office based project with training programme will be conducted in a company or organisation approved by the Department of Chemistry. The content will depend on the precise requirements of the placement company.

CH30083: Study period abroad (MChem - half year)

Credits: 21

Level: Honours

Academic Year

Assessment: OT100

Requisites:

While taking this unit you must take CH30081 and take CH40092 and take CH40130 and in taking this unit you cannot take CH30055 or take CH30060

Only available to students on M.Chem programmes with a study year abroad component.
Aims & Learning Objectives:
Students will gain experience of living and studying in a University outside the UK. They will have the opportunity to develop personal and linguistic skills in addition to developing their knowledge and understanding of chemistry and its applications. After studying this Unit, students should be able to:
* develop personal and interpersonal communication skills;
* demonstrate the ability to work and interact effectively in a group environment in which cultural norms and ways of operating may be unfamiliar;
* operate effectively with people from a different cultural background;
* (where appropriate) improve their knowledge of the host language by attending classes therein and interacting with native speakers.
Content:
A period of up to 6 months will be spent in an approved University outside the UK. The precise programme of study will normally involve a project in a chemical science as well as attendance at appropriate other classes. The programme will vary considerably depending on the host University but will be largely related to the chemical sciences and will be agreed in advance with the Director of Studies. The academic level of the programme will be at a similar level to those taken by Year 3 MChem students at Bath.

CH30084: Study period abroad (BSc - half year)

Credits: 30

Level: Honours

Academic Year

Assessment: RT100

Requisites:

While taking this unit you must take CH30082 and in taking this unit you cannot take CH30058 and take CH30054

Only available to students on BSc programmes Study Year Abroad with Industrial Experience.
Aims & Learning Objectives:
Students will gain experience of living and studying in a University outside the UK. They will have the opportunity to develop personal and linguistic skills in addition to developing their knowledge and understanding of chemistry and its applications. After studying this unit, students should be able to:
* develop personal and interpersonal communication skills;
* demonstrate the ability to work and interact effectively in a group environment in which cultural norms and ways of operating may be unfamiliar;
* operate effectively with people from a different cultural background;
* (where appropriate) improve their knowledge of the host language by attending classes therein and interacting with native speakers.
Content:
A period of up to 6 months will be spent at an approved University outside the UK. The precise programme of study will normally involve a short research project as well as attendance at appropriate other classes. The programme will vary considerably depending on the host University but will be agreed in advance with the Director of Studies.

CH30086: Inorganic chemistry in biological systems

Credits: 3

Level: Honours

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must (take CH20013 and take CH20014 and take CH20015) or (take CH20078 and take CH20079) and in taking this unit you cannot take CH40086

Aims & Learning Objectives:
The overall aim of this course is to provide an introduction to bio-inorganic chemistry with a focus on the role of d- and f-block elements in biology. At the end of this unit, students should be able to:
* Demonstrate an understanding of how and why the coordination chemistry of metals are used in biological systems.
* Account for the considerable current research attention attracted by transition metals in bioinorganic chemistry.
* Account for the bonding features relating to structural and reactivity patterns.
Content:
Metals in biology - basic coordination chemistry and analytical methods used in bioinorganic chemistry - metal containing enzyme systems - structural role of metals - metals in medicine.

CH30098: Topics in drug discovery

Credits: 3

Level: Honours

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014 and take CH20097

Aims: The Unit aims to provide a description of the processes of target selection, drug candidate selection and optimisation. It is anticipated that students will be able to relate this to the progress of drug candidates through clinical trials and on to market. The Unit aims to provide opportunities for students to develop their knowledge of these areas and to solve associated problems independently and in group situations. It is anticipated that the students will have the learning outomes identified below.
Learning Outcomes:
After studying the Unit, students should be able to:
* account for the importance of selected key therapeutic areas
* recognise leading pharmaceutical drugs and propose methods for their synthesis
* describe the processes of lead identification and lead optimisation
* describe some modern methods of combinational and high throughput chemistry
* compare and contrast discovery chemistry and development chemistry approaches
* demonstrate an appreciation of the issues involved in taking drug candidates through clinical trials and on to market.
Skills:
Problem solving (T, F, A), Scientific writing (F, A), Independent working (F), Group working (F).
Content:
Key therapeutic areas (for example, drugs for hypertension, heart disease, cancer, arthritis, disorders of the central nervous system). The relevance of patents and patent breaking to the pharmaceutical industry. The approaches taken in lead identification. Combinational and high throughput chemistry methodologies and data mining. Modern approaches to lead optimisation. Case studies comparing discovery chemistry and development chemistry approaches to the synthesis of drug candidates. Natural products and their derivatives as pharmaceutical agents. Overview of clinical trials and marketing issues.

CH30127: Topics in inorganic chemistry

Credits: 6

Level: Honours

Semester: 1

Assessment: EX100

Requisites:

Before taking this unit you must take CH20013 and take CH20015 and take CH20095 and in taking this unit you cannot take CH30030

Aims: To introduce the principles of the chemistry of the heavy transition metals, the lanthanides and actinides and selected topics in P-block chemistry, with emphasis on the elements of Groups 13 - 15.
Learning Outcomes:
After studying the Unit, students should be able to:
* explain the systematic trends across the d-block elements.
* contrast the differences down individual d-block triads.
* rationalise the chemistry of lanthanide and actinide compounds in terms of oxidation state and coordination number.
* describe the synthesis, structure, bonding and factors effecting stability of main group metallocene compounds.
* describe the properties and reactivity and factors effecting stability of heavy p-block containing compounds
* understand the role of MOCVD in the electronics industry
* rationalise the synthesis of precursors for MOCVD
* know the basic chemistry of key inorganic polymers.
Skills:
Problem solving (T, F, A), Scientific writing (F, A), Independent working (F), Group working (F).
Content:
A description of the chemistry of the second and third row d-block elements. The contrast between the chemistry of these heavier d-block elements with those of the first row. Selected chemistry of a d-block triad. A description of the chemistry of the lanthanide and actinide elements. A comparison of this chemistry with that of s, p and d-block elements. Magnetic and spectroscopic properties of the complexes of these elements.
The synthesis and stability of low oxidation state main group organometallic systems (Main group Cp-compounds, Lone-pair effects, Singlet vs Triplet state systems). A Survey of the synthesis, structure and bonding of homo-metallic Main group multiple bonded systems. A study of selected heavier heteroatomic multiple bonded systems (e.g. M=O, M=C etc): Cyclic and acyclic. Main Group Chemistry and the Electronics Industry; MOCVD. The chemistry of selected inorganic polymers.

CH30128: Topics in organic chemistry

Credits: 6

Level: Honours

Semester: 1

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014 or take CH20078

In taking this unit you cannot take Recent developments in organic chemistry as a component of CH30061.
Aims: The aim of the unit is to give students a thorough grounding in the methods, strategies and reagents employed in modern stereoselective organic synthesis.
Learning Outcomes:
After studying this unit students should be able to:
* Analyse the stereochemical course of a variety of reactions.
* Describe reagent systems to effect a wide range of simple transformation.
* Appreciate why organoelement chemistry is used in synthesis.
* Describe a wide range of new synthetic transformations.
* Describe fully the mechanism of these reactions.
* Apply the information learnt to solve problems.
Skills:
Problem solving (T, F, A), Scientific writing (F, A), Independent working (F), Group working (F).
Content:
The unit begins with a section concerned with the simple diastereoselection, focusing on the reactions of carbonyl and alkene systems. The concepts of allylic strain and directed reactions are introduced. the use of chiral auxiliaries to control the sterochemistry of organic reactions forms the second section. Particular systems studied include the use of SAMP and RAMP hydrozones and Evans' auxiliaries to control a range of chiral-enolate based bond constructions. The final section of the unit focuses on the development and application of practical enantioselective catalysts of particular relevance to the fine chemical industry. Examplse of transformations to be studied will include hydrogenation of double bonds, oxidations and carbon-carbon bond forming reactions. Organoboron chemistry. Organosilicon chemistry. Organophosphorus chemistry. Organosulphur chemistry. Organometallics in Organic synthesis. Carbonylation reactions. Coupling Reactions. Methods of C-C bond formation.

CH30129: Topics in physical chemistry

Credits: 6

Level: Honours

Semester: 1

Assessment: EX100

Requisites:

In taking this unit you cannot take CH30074

In taking this unit you may not take polymer chemistry as a component of CH30061.
Aims: This core unit will introduce the basic concepts needed to describe the synthesis and characterisation of a range of polymers in order to understand how their properties can be controlled. The basic principles of photochemistry taught in previous units will be reinforced and techniques for the study of and applications of photochemistry will be introduced.
Learning Outcomes:
After studying this unit students should be able to :
* Demonstrate an understanding of how polymer structures can be influenced by the methods of synthesis by step- and chain growth polymerisation.
* Account for the formation and decay of electronically excited states in molecules.
* Describe modern instrumental methods for photochemical investigation.
* Solve a range of quantitative problems in these topics.
Skills:
Problem solving (T, F, A), Scientific Writing (F, A), Independent working (F), Group working (F).
Content:
Classification and types of polymers. Synthesis of polymers with examples taken from several different classes (addition, step-growth, ring opening, organometallic) with the emphasis on how physicochemical considerations influence the polymer structure. Characterisation of polymers (molecular weight and chain length, spectroscopy, thermal methods). Structure and morphology of polymers and how this influences properties. Polymer solutions and thermodynamics of polymer mixtures. A survey of recent applications taken from current research and industrial topics.Absorption and emission of light. Jablonskii scheme. Excited state kinetics and quenching. Experimental methods. Properties and reactions of excited states. Examples of photochemical processes including photosynthesis, photography, solar energy conversion and atmospheric photochemistry.

CH30132: Chemistry research project (Natural Sciences)

Credits: 12

Level: Honours

Academic Year

Assessment: EX35OT65

Requisites:

Before taking this unit you must take CH20078 and take CH10005 and (take CH20017 or take CH20079) and (take CH10005 or take CH10094)

Aims: To allow students on the Natural Sciences programme to experience a practical or theoretical/computational research project typical of research in an academic environment. To further develop and reinforce the skills necessary for research work. To enhance the students chemistry knowledge and develop independent work and data analysis.
Learning Outcomes:
After studying the Unit, students should be able to:
* Demonstrate advanced experimental techniques appropriate to the chosen project.
* Record experimental observations and data in an efficient manner.
* Present results in a variety of formats and place them into context of other researchers' work.
* Demonstrate the ability to plan and conduct an experimental programme.
Skills:
Problem solving (T, F, A), data collection and analysis, scientific writing (F, A), independent working (F).
Content:
A research topic will be selected in conjunction with a supervising member of staff and a program of experimental work planned. In addition to the experimental aspects, appropriate library work will be conducted. Aspects of project planning, safety, report writing skills and oral presentations will be introducted as appropriate.

CH30141: Topics in catalysis for organic synthesis

Credits: 3

Level: Honours

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014 and take CH30070 and take CH30071 and in taking this unit you cannot take CH40141

Aims: To describe and demonstrate recent techniques in the application of catalysis to the synthesis of organic molecules. To illustrate how either metal-complexes or organocatalysts can be applied to the asymmetric synthesis of valuable intermediates.
Learning Outcomes:
After studying the Unit, students should be able to:
* Describe a range of catalytic systems for achieving important synthetic transformations
* Account for the importance of asymmetric catalysis in organic synthesis
* Integrate catalytic techniques with retrosynthetic analysis to introduce new stereocentres to organic molecules
* Apply the techniques introduced in this unit to the synthesis of complex molecules.
Skills:
Problem solving (T, F, A), Scientific writing (F, A), Independent working (F).
Content:
The development of chiral Lewis acids and their application in a range of synthetic transformations. A complementary approach to asymmetric synthesis using organocatalysis. Enantioselective palladium and rhodium catalysed carbon-carbon bond forming processes. A review of recent developments in the area of catalysis applied to organic synthesis. The application of catalysis to the synthesis of complex molecules.

CH30144: Dissertation

Credits: 12

Level: Honours

Semester: 2

Assessment: DS65OR35

Requisites:

In taking this unit you cannot take CH30063

Aims: The aim of the unit is that students gain skills in conducting an in-depth analysis on a chemically-related topic, by collating and reviewing original data and presenting the work in written review form. The dissertation should not simply state fact but attempt to identify trends and exceptions within the data reviewed.
Learning Outcomes:
On completing this unit a student should be able to:
* use a variety of methods in searching for information from a range of information sources, on a chemistry-related topic,
* carefully review this information
* assess the reliability and importance of individual pieces of information according to their sources and relevance to the topic under study
* construct an structured, well-argued and analytical dissertation using the information sourced
* defend their analysis of the topic studied in an oral examination based on the dissertation material.
Skills:
Planning and organisation (T/F/A), Study skills (F), Information and communication technology (T/F/A), Written communication (T/F/A), Oral communication (T/F/A).
Content:
A chemistry topic suitable for review and requiring access to primary data will be chosen by each student from a list provided. A tutor will be assigned to each student to monitor progress, give advice and assess the dissertation and (in part) participate in the oral examination. Students will attend a presentation by the Chemistry Librarian at the start of the academic year on information sources.

CH40033: Electrochemistry and surfaces

Credits: 3

Level: Masters

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20016 and in taking this unit you cannot take CH30033

Aims & Learning Objectives:
This course provides an introduction to both kinetic electrochemistry and modern methods of modifying and studying surfaces including Surface Plasmon Resonance, Plasmon Fluorescence. Additionally, methods of modifying surfaces with molecules and polymers to make e.g. sensor devices will be discussed. After studying the Unit, students should be able to:
* Define the relationship between mass transport and electron transfer processes in electrochemical measurements.
* Analyse current-voltage behaviour potential step and cyclic voltammetry measurements.
* Understand how a molecular build up approach can be used to make functional surfaces.
* Understand how SPR, electrochemistry and impedance, can be used to gain real time information about molecular adsorption and protein-molecule binding.
* Demonstrate a thorough understanding of how the techniques can be applied to novel situations i.e. to develop new biosensors on systems they have not been taught about in the course.
Content:
Introduction and revision of basic concepts in electrochemisty, Electrode kinetics and deriving the Nernst & Butler-Volmer equation, Coupled electron transfer and chemical reactions: EC, ECE and ECE' mechanisms. The glucose biosensor, Methods to improve signal noise: Square Wave & Pulse voltammetry, thin layer cells. Bioelectrochemisty. Surface modification: Self-assembled Monolayers and Polymers. Surface Plasmon Resonance: Theory and Application. Kinetic analysis of surface binding. Impedance Spectroscopy: Analysis of thin films at surfaces. Scanning Force Microsopies. Fluorescence methods.

CH40036: Biopolymers

Credits: 3

Level: Masters

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014 and while taking this unit it is recommended that you take CH30039 or take CH40039 and in taking this unit you cannot take CH30036

Aims & Learning Objectives:
To provide an overview of biopolymer structures (carbohydrates, nucleic acids). This overview will form a basis for students to appreciate selected recent developments in carbohydrate and nucleic acid chemistry. After studying this unit, students should be able to:
* Show an appreciation of carbohydrate and nucleic acid chemisty.
* Determine the structure of an unknown polysaccharide.
* Explain what is meant by the terms gene and clone.
* Describe how DNA can be manipulated in the test tube.
* Describe how DNA analysis is useful in forensic science and archeology.
* Apply knowledge to problem-solving exercises in carbohydrate and nucleic acid chemistry.
* Critically evaluate publications from the recent literatire to illustrate the course themes.
* Demonstrate knowledge of selected recent developments in carbohydrate and nucleic acid chemistry.
Content:
Monosaccharide and oligosaccharide chemistry and stereochemistry. Carbohydrates as acetals and hemiacetals, relating them to mainstream organic chemistry. Application of NMR spectroscopy to carbohydrate structures. Synthesis of disaccharides with an emphasis on protecting group strategies. The diversity of naturally occurring carbohydrates in a monomeric and polymeric form and their role in biochemistry. Brief summary of DNA and genes. Manipulating (cutting, pasting and amplifying) DNA with enzymes. DNA fingerprinting and crime/paternity cases. Ancient DNA and archeology. Nanomachines made of DNA.

CH40037: Synthesis of medicinal compounds

Credits: 3

Level: Masters

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20014 and in taking this unit you cannot take CH30037

Aims & Learning Objectives:
To introduce and illustrate how advanced synthetic organic chemistry is used in the preparation of medicinally valuable compounds with an emphasis on synthetic planning and execution. After studying this Unitm students should be able to:
* Describe several methods for preparing compound libraries based on a given framework.
* Apply the concept of Solid Phase Organic Synthesis (SPOS) to combinatorial chemistry.
* Define reagents and strategies for the assembly of defined stereochemical arrays.
* Design rational analogues, or modified compounds from given medicinal agents.
* Analyse and use reterosynthetic methods to plan synthetic routes to a range of complex target molecules.
Content:
The unit will illustrate the complex relationship between organic chemistry and medicine: Introduction to combinatorial chemistry. Solid Phase Organic Synthesis (SPOS), resins and linkers. Parallel synthesis. Case studies. In addition, several disease areas will be selected and compounds used to treat them considered. The focus of the unit will be the methods used to synthesise those compounds and in particular the synthetic strategies employed. Areas covered will include:- Prostaglandins, b-Lactams, ionophoro antibiotics and anti-cancer drugs.

CH40038: Neutron scattering for chemists

Credits: 3

Level: Masters

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20016 and in taking this unit you cannot take CH30038

Aims & Learning Objectives:
To provide an introduction to the theory and practice of modern neutron scattering as applied to chemical systems. After studying this Unit, students should be able to:
* Define and describe scattering parameters for neutrons.
* Describe typical neutron scattering experimental set-up.
* Discuss the use of isotopic substitution and contrast variation.
* Discuss and detailed analysis of small angle scattering data.
* Discuss and detailed analysis of neutron scattering from interfaces.
* Study a recent neutron experiment from literature.
Content:
Introduction: Why neutrons? Scattering theory. Properties of the neutron and production of high fluxes. Experimental detail - neutron spectrometers. Detection of neutrons. Coherent and Incoherent scattering. Elastic and inelastic scattering. Small Angle scattering. Neutron reflection.

CH40039: Computational chemistry

Credits: 3

Level: Masters

Semester: 2

Assessment: EX100

Requisites:

In taking this unit you cannot take CH30039

Aims & Learning Objectives:
To provide an introduction to computational chemistry describing the range of chemical problems relating to inorganic materials that are accessible to these techniques. To present some of the latest research developments, particularly where electronic structure methods are also employed. After studying the Unit, students should be able to:
* demonstrate the relationship between interatomic forces and chemical properties and identify where computer simulation techniques can be used.
* describe the usefulness and limitations of selected methods in a variety of chemical situations.
* be able to make a critical analysis of a research paper in computational chemistry.
* describe the value of density functional techniques in modern computational chemistry of materials.
Content:
Definitions of terms such as ensembles and periodic boundaries. Description of energy minimisation methods. Introduction to zeolite catalysts and the role of energy minimisation in understanding their properties. Introduction to molecular dynamics and its use in calculating thermodynamic and diffusion properties. The role of molecular dynamics in modelling diffusion. Introduction to Monte Carlo techniques, including applications e.g. crystal growth. Describe recent developments for modelling interfaces and density functional methods.

CH40040: Chemistry research project

Credits: 12

Level: Masters

Semester: 1

Assessment: EX30DS30OT40

Requisites:

While taking this unit you must take CH40049 and in taking this unit you cannot take CH30063 or take CH30050 or take CH40047 or take CH40048

Only available to students on MChem Sandwich programmes Year 4.
Aims & Learning Objectives:
To allow students to experience a practical research project typical of research in an academic environment. To further develop and reinforce the skills necessary for research work. After studying the Unit, students should be able to:
* Demonstrate advanced experimental techniques appropriate to the chosen project.
* Record experimental observations and data in an efficient manner.
* Present results in a variety of formats and place them into context of other researchers' work.
* Demonstrate the ability to plan and conduct an experimental programme.
Content:
A research topic will be selected in conjunction with a supervising member of staff and a program of experimental work planned. In addition to the experimental aspects, appropriate library work will be conducted. Aspects of project planning, safety, report writing skills and oral presentations will be introduced as appropriate.

CH40042: Inorganic cages & clusters

Credits: 3

Level: Masters

Semester: 2

Assessment: EX100

Requisites:

Before taking this unit you must take CH20015 and in taking this unit you cannot take CH30042

Aims & Learning Objectives:
To introduce the principles of main group (esp. boranes) and transition metal cluster chemistry including methods of synthesis, reactivity and a description of the bonding within these sytems. After studying this Unit, students should be able to:
* Predict the structure and reactivity of boranes, heteroboranes and metalloboranes.
* Rationalise the structure of transition metal clusters.
* Describe the synthesis of low nuclearity transition metal clusters.
* Critically assess current literature in the field.
* Describe recent advances in cluster chemistry.
* Be able to rationalise structures and reactivity, using the ideas encountered, in wider chemistry context. Content:Boron Hydrides - introduction and cluster shapes. Wade's Rules - predicting cluster shape. M.O. theory and Wade's rules. Isolobal Theory. Metalloboranes. Synthesis of Boron hydride compounds. Reactivity of Boron hydride compounds. Clusters with main group elements other than boron (Zintl ions, P₄ etc)Types of transition metal clusters. Metal framework structures. The role of the ligands - carbonyls, hydrides, phosphines. Structure and bonding in clusters. Extension of Wade's rules to metal clusters. Mingos condensed polyhedral approach. Synthesis and characterization of metal carbonyl clusters. Pyrolysis, thermolysis, redox condensations. Cluster build up reactions. Ligand reactivity - hydrides and carbonyls. Clusters in catalysis.

CH40047: Advanced chemistry research project

Credits: 24

Level: Masters

Semester: 1

Assessment: EX30DS30OT40

Requisites:

While taking this unit you must take CH40048 and in taking this unit you cannot take CH30063 or take CH30050 or take CH40040 or take CH40049

Only available to students on MChem (non-Sandwich) programmes Year 4.
Aims & Learning Objectives:
To allow students to experience a practical research project typical of research in an academic environment. To further develop and reinforce the skills necessary for research work. After studying the Unit, students should be able to:
* Demonstrate advanced experimental techniques appropriate to the chosen project.
* Record experimental observations and data in an efficient manner.
* Present results in a variety of formats and place them into context of other researchers' work.
* Demonstrate the ability to plan and conduct an experimental programme.
Content:
A research topic will be selected in conjunction with a supervising member of staff and a program of experimental work planned. In addition to the experimental aspects, appropriate library work will be conducted. Aspects of project planning, safety, report writing skills and oral presentations will be introduced as appropriate.

CH40048: Advanced chemistry research project

Credits: 18

Level: Masters

Semester: 2

Assessment: EX30DS30OT40

Requisites:

While taking this unit you must take CH40047 and in taking this unit you cannot take CH30063 or take CH30050 or take CH40040 or take CH40049

Credits: 6

Level: Masters

Semester: 1

Assessment: RT60OR40

Requisites:

Aims & Learning Objectives:
To enhance the skills necessary in retrieving information from a variety of Chemical Literature sources and preparation of an in-depth report on a topic at the frontier of chemistry. After studying the Unit, students should be able to:
* Recognise and use appropriate text and electronic sources of chemical information;
* Assemble information from a number of sources into a coherent report'
* Evaluate critically the chemical literature;
* Demonstrate a systematic understanding of a chosen topic;
* Formulate hypotheses and devise experiments to test these hypotheses;
* Prepare and deliver an oral presentation using appropriate visual aids.
Content:
In conjunction with a supervisor, a topic of recent research or other chemical significance will be selected. Several key references will be identified by the student and the student will use these as a basis to prepare a detailed, critical survey of the area. In addition to 'paper' sources, computer-based data retrieval systems will be used. Where appropriate, students will formulate hypotheses and propse new experiments to test these hypotheses. Students will prepare a written report and also a long oral presentation on the selected topic.

CH50102: Advanced group work in practical chemistry

Credits: 6

Level: Masters

Semester: 1

Assessment: RT25CW50OR25

Requisites:

Aims & Learning Objectives:
To introduce students to an extended piece of practical chemistry involving planning and executing experimental work and reporting the results in a number of formats. Transferable skills such as communication and teamwork will be emphasised. After completing this Unit, students should be able to:
* Demonstrate skills in planning and executing practical problems in Chemistry;
* Work in a team - allocation and correlation of tasks and collection of data;
* Present the results of an investigation in written report and poster formats;
* Demonstrate experimental skills appropriate to the chosen project to a high level;
* Demonstrate a comprehensive understanding of techniques used;
* Present a new technique not covered in the main course.
Content:
Students will work in small groups on problems of an investigative nature selected from a list of available projects. A problem will be set and appropriate experimental protocols will need to be researched and designed. After completion of the work, a variety of reporting formats will be used (poster, report) to emphasise students' communication skills. An oral presentation demonstrating a technique not covered in the main practical course will be given.

CH50103: Advanced research projects

Credits: 48

Level: Masters

Semester: 2

Assessment: DS55OR45

Requisites:

Before taking this unit you must take CH50102

Aims: To allow students to experience a practical research project typical of research in an academic environment. To further develop and reinforce the skills necessary for research work.
Learning Outcomes:
After studying the Unit, students should be able to:
* Demonstrate advanced experimental techniques appropriate to the chosen project and develop them to a high level;
* Demonstrate a comprehensive understanding of these techniques;
* Record experimental observations and data in an efficient manner;
* Present results in a variety of formats and place them in context of other researchers' work;
* Demonstrate a critical awareness of the scientific literature in relation to the chosen research areas;
* Demonstrate the ability to plan and conduct an experimental programme;
* Devise new hypotheses, and experiments to test these hypotheses;
* Demonstrate originaltiy in tackling and solving problems.
Skills:
Numeracy (F, A); Problem solving (T, F, A): Scientific writing (F, A); Independent working (F).
Content:
Two different research projects will be selected in conjunction with a supervising member of staff (one for each project) and a program of experimental work planned. In addition to the experimental aspects, appropriate library work will be conducted. Aspects of project planning, safety, report writing skills and oral presentations will be introduced and developed as appropriate.

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