Department of Biology & Biochemistry, Unit Catalogue 2007/08 |
BB40102 Molecular mechanisms of disease |
| Credits: 6 |
| Level: Masters |
| Semester: 1 |
| Assessment: CW 100% |
| Requisites: |
| In taking this unit you cannot take BB40085 or take BB40118 or take BB40124 and before taking this unit you must take BB20024 and take BB10003 |
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or you must have taken suitable degree units from another University.
Aims: To describe how a defect at the level of the gene results in an observed disease phenotype. To show how such patients can be treated with modern molecular medicine.
Learning Outcomes: After taking this course the student should be able to: * understand the common themes of genetic disorders, and how they relate to the overall phenotype; * understand the principles of tools involved in diagnosis and treatment of the disorders. Skills: Learning and studying T/F/A, Written communication T/F/A, Information handling & retrieval T/F/A, Working independently T/F/A, oral presentation T/F/A. Content: Diseases: diabetes, glycogen storage diseases, hyperbilirubinaemia, familial hypercholesterolaemia, fibroblast growth factor receptors and skeletal dysplasia. Diagnosis and treatment: PCR/cloning, antibody engineering, gene therapy, gene targeting in the mouse, mouse models for human disease. |