Aims & Learning Objectives:
Aims: To provide an advanced study of genome structure and expression in eukaryotes.
After taking this course the student should be able to:
* appreciate the complexities of gene regulation and the various stages at which expression is regulated;
* review the ways in which mRNA differs from the primary transcript;
* know how to use genome structural information to distinguish between individuals;
* devise a strategy for the identification and mapping of disease genes.
Content:
Genome structure and mapping (genetic & physical). Applications of genomics and genome evolution. Assembly of the eukaryotic RNA synthetic machinery and its regulation by transcription factors. Chromatin remodelling in transcription. RNA splicing, editing and other modifications and their control.
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