Department of Biology & Biochemistry, Unit Catalogue 2007/08 |
BB30162 Protein synthesis, folding and turnover |
| Credits: 6 |
| Level: Honours |
| Semester: 1 |
| Assessment: CW 20%, EX 80% |
| Requisites: |
| Before taking this unit you must take BB20023 |
|
Aims:
* To introduce the process of transcription in prokaryotes. * To provide an understanding of ribosome structure and mRNA translation in both prokaryotes and eukaryotes. * To detail the process of protein folding and the intracellular pathways of folding and post-translational modification. * To explain the various pathways of intracellular and extracellular protein turnover. * To provide students with an integrated and comprehensive view of the key processes controlling the production and turnover of cellular proteins. Learning Outcomes: After taking this unit, the student should have an integrated understanding of the cellular processes involved in gene expression and protein turnover. They should be able to: * Describe and explain how bacterial gene expression is regulated at the transcriptional level. * Describe and explain the process of translation. * Explain and critically evaluate our current understanding of the processes involved in protein folding * Describe the pathways and explain the importance of protein turnover * Analyse the strengths and limitations for current predictive methods for protein structure. Skills: Learning and studying T/FA, Written communication T/FA, Information handling & retrieval T/FA, Working independently T/F, Information technology T/FA. Content: Prokaryotic transcription (5 lectures) Translation (5 lectures) Protein Folding (5 lectures) Protein Turnover (5 lectures) Computational approaches to the prediction of protein folding (practical) (16 hr). |