Department of Biology & Biochemistry, Unit Catalogue 2009/10 |
BB40102: Molecular mechanisms of disease |
 Credits:
| 6 |
| Level:
| Masters |
| Period: | Semester 1 |
| Assessment:
| CW 100% |
| Supplementary Assessment: | Like-for-like reassessment (where allowed by programme regulations) |
| Requisites:
| In taking this unit you cannot take BB40085 or take BB40118 or take BB40124 and before taking this unit you must take BB20024 and take BB10003 |
| Description: | or you must have taken suitable degree units from another University. Aims: To describe how a defect at the level of the gene results in an observed disease phenotype. To show how such patients can be treated with modern molecular medicine. Learning Outcomes: After taking this course the student should be able to: * explain the common themes of genetic disorders, and how they relate to the overall phenotype; * explain the principles of tools involved in diagnosis and treatment of the disorders. Skills: Learning and studying T/F/A, Written communication T/F/A, Oral communication T/F/A, Information handling & retrieval T/F/A, Working independently T/F/A. Content: Diseases: diabetes, glycogen storage diseases, hyperbilirubinaemia, familial hypercholesterolaemia, fibroblast growth factor receptors and skeletal dysplasia. Diagnosis and treatment: PCR/cloning, antibody engineering, gene therapy, gene targeting in the mouse, mouse models for human disease. |