|
 Academic Year:
| 2013/4 |
| Owning Department/School:
| Department of Chemistry |
| Credits:
| 6 |
| Level:
| Intermediate (FHEQ level 5) |
| Period: |
Semester 1 |
| Assessment:
| EX 100% |
| Supplementary Assessment: |
Like-for-like reassessment (where allowed by programme regulations) |
| Requisites:
| In taking this unit you cannot take CH20149 or take CH20150 |
| Description:
| Aims: To provide the student with a working knowledge of important classes of organic transformations give an overview of retrosynthetic analysis as a valuable method for the design of an organic molecule. Learning Outcomes: After studying this Unit, students should be able to: * interpret and predict NMR spectra and mass spectra; * account for the importance of stereoselectivity in organic synthesis; * demonstrate the important relationship between structure and reactivity for organic molecules; * design syntheses of heterocyclic and alicyclic compounds from common starting materials apply retrosynthesis methods to a selected range of compounds. Skills: Problem solving (T, F, A), Data Analysis (T, F, A), Independent working (F), Group working (F). Content: Interpretation of NMR spectra including homotopic and diastereotopic protons. Correlation spectroscopy. Mass spectrometry. The principles of retrosynthesis. The use of carbon nucleophiles in retrosynthesis. Malonate ester synthesis and applications. Umpolung reagents. Alkene synthesis, including Wittig reaction. Oxidation reactions of alkenes and alcohols. Reduction reactions of ketones and other carbonyl compounds. Review of aromatic chemistry. Description, reactivity and synthesis of heterocycles including pyrroles, furan, thiophene, pyridine and indoles. Synthesis and reactivity of naphthalene, quinolines and isoquinolines. Concepts of organopalladium chemistry. Concepts of combinatorial chemistry for the synthesis of libraries of heterocycles. |
| Programme availability: |
CH20176 is Optional on the following programmes:Department of Chemistry
|