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PA30287: Medicines design 3: advanced drug delivery

Follow this link for further information on academic years Academic Year: 2013/4
Further information on owning departmentsOwning Department/School: Department of Pharmacy & Pharmacology
Further information on credits Credits: 6
Further information on unit levels Level: Honours (FHEQ level 6)
Further information on teaching periods Period: Semester 2
Further information on unit assessment Assessment: EX 100%, OT 0%
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this unit you must take PA10281 and take PA20285 and take PA30286
Further information on descriptions Description: Aims:
To learn about (a) non-oral routes of drug delivery, (b) advanced drug delivery systems (c) delivery of biopharmaceuticals and (d) integration of physiology with dosage forms and pharmacokinetics.

Learning Outcomes:
By the end of the unit the student will be able to:
1. Compare and contrast the non-oral routes of drug delivery (nasal, pulmonary, vaginal, sublingual, buccal, topical and transdermal). Analyze which route of administration is more appropriate for a given drug therapy. Evaluate the requirements imposed to medicines by the desired route of administration.
2. Compare and contrast the dosage forms used to deliver drugs via the non-oral routes of drug delivery. Examine the key technology parameters involved in their formulation and performance.
3. Evaluate and differentiate advanced drug delivery systems: oral (enteric, delayed and controlled release), implantable, and liposome, nanoparticle - based medicines.
4. Analyse the challenges involved in delivery biopharmaceuticals.
5. Illustrate how disease and drug interactions modifies drug pharmacokinetics
6. Integrate physiology with dosage forms performance.

Skills:
1. Data analysis and integration
2. Problem solving
3. Analytical thinking
4. Scientific skills
5. Handling information
6. Lateral thinking
7. Professional
All taught and assessed

Content:
1. The nasal and pulmonary routes of drug delivery. Related dosage forms: Inhalers.
2. Other routes of drug delivery: vaginal, sublingual, buccal.
3. The transdermal and topical route of drug delivery. Related dosage forms.
4. Advanced oral delivery systems: enteric, delayed and controlled DDS
5. Advanced parenteral drug delivery systems. Implantable dosage forms
6. Targeted drug delivery systems.
7. Biopharmaceuticals: peptides, proteins, vaccines, antibodies, gene and DNA
8. Effect of disease and drug interaction on pharmacokinetics.
9. Integration: physiology, dosage form and pharmacokinetics.
Further information on programme availabilityProgramme availability:

PA30287 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology
Notes:
* This unit catalogue is applicable for the 2013/4 academic year only. Students continuing their studies into 2014/15 and beyond should not assume that this unit will be available in future years in the format displayed here for 2013/14.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.