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2014/5 |
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Department of Chemistry |
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3 |
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Honours (FHEQ level 6) |
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Semester 2 |
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EX 100% |
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Like-for-like reassessment (where allowed by programme regulations) |
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Before taking this unit you must take CH20149 or take CH20150. This unit is not available to students on placement or study abroad programmes. |
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Aims: To teach aspects of supramolecular chemistry with an emphasis on (bio)chemical recognition and sensing. Learning Outcomes: After taking this course the student should be able to: * Identify and discriminate the relevant supramolecular interactions based on the solvent system; * Describe analytical techniques used to investigate supramolecular interactions; * Understand the role of solvation in molecular recognition and chemical reactivity; * Describe dynamic combinatorial chemistry; * Explain the enthalpic and entropic contributions in molecular recognition; * Identify and describe different types of sensors; * Design basic on/off and off/on molecular sensors; * Explain the difference between sensing and sequestering; * Describe molecular carriers and cellular channels and their mode of action. Skills: Learning and studying T/F/A, Written communication T/F/A, Numeracy & computation T/F/A, Problem solving T/F, Information handling & retrieval T/F/A, Working independently T/F, Career preparation T/F. Content: Supramolecular Chemistry: Concepts and definition; Classification of supramolecular interactions; Cooperativity, effective molarity and chelate effect; Highlights of supramolecular interactions in nature. Solvation and solvophobic effects. Characterisation of supramolecular systems. Supramolecular chemistry through design: Small molecule receptors; Small molecule guests for biological targets; Supramolecular polymers. Dynamic combinatorial chemistry: Types of reversible chemistry; Analytical methods. Solution Host-Guest Chemistry: Cation receptors; Anion receptors; Neutral molecule receptors; Ditopic receptors. Sensors. Natural and artificial channels. |
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CH30211 is Optional on the following programmes:Department of Chemistry
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