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CH40211: Chemistry beyond the molecule

Follow this link for further information on academic years Academic Year: 2014/5
Further information on owning departmentsOwning Department/School: Department of Chemistry
Further information on credits Credits: 3
Further information on unit levels Level: Masters UG & PG (FHEQ level 7)
Further information on teaching periods Period: Semester 2
Further information on unit assessment Assessment Summary: EX 100%
Further information on unit assessment Assessment Detail:
  • Exam (EX 100%)
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this unit you must take CH20149 or take CH20150 and in taking this unit you cannot take CH30211
Further information on descriptions Description: Aims:
To teach aspects of supramolecular chemistry with an emphasis on (bio)chemical recognition and sensing.

Learning Outcomes:
After taking this course the student should be able to:
* Identify and discriminate the relevant supramolecular interactions based on the solvent system;
* Describe analytical techniques used to investigate supramolecular interactions;
* Understand the role of solvation in molecular recognition and chemical reactivity;
* Describe dynamic combinatorial chemistry;
* Explain the enthalpic and entropic contributions in molecular recognition;
* Identify and describe different types of sensors;
* Design basic on/off and off/on molecular sensors;
* Explain the difference between sensing and sequestering;
* Describe molecular carriers and cellular channels and their mode of action;
* Solve unseen problems relating to supramolecular chemistry;
* Critically evaluate examples of supramolecular chemistry from the current literature.

Skills:
Learning and studying T/F/A, Written communication T/F/A, Numeracy & computation T/F/A, Problem solving T/F, Information handling & retrieval T/F/A, Working independently T/F, Career preparation T/F.

Content:
Supramolecular Chemistry: Concepts and definition; Classification of supramolecular interactions; Cooperativity, effective molarity and chelate effect; Highlights of supramolecular interactions in nature. Solvation and solvophobic effects. Characterisation of supramolecular systems. Supramolecular chemistry through design: Small molecule receptors; Small molecule guests for biological targets; Supramolecular polymers. Dynamic combinatorial chemistry: Types of reversible chemistry; Analytical methods. Solution Host-Guest Chemistry: Cation receptors; Anion receptors; Neutral molecule receptors; Ditopic receptors. Sensors. Natural and artificial channels.
Further information on programme availabilityProgramme availability:

CH40211 is Optional on the following programmes:

Department of Chemistry
  • USCH-AAM03 : MChem(Hons) Chemistry with Study year abroad (Year 4)
  • USCH-AAM06 : MChem(Hons) Chemistry for Drug Discovery with Study year abroad (Year 4)
  • USCH-AKM03 : MChem(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 4)
  • USCH-AKM02 : MChem(Hons) Chemistry with Industrial Placement (Year 4)
  • USCH-AFM07 : MSci(Hons) Chemistry with Management (Year 4)
  • USCH-AKM07 : MSci(Hons) Chemistry with Management with Industrial Placement (Year 5)
  • RSCH-AFM03 : Integrated PhD in Chemistry
  • TSCH-AFM01 : MRes Chemistry
  • TSCH-AFM04 : MSc Chemistry for Drug Discovery

Notes:
* This unit catalogue is applicable for the 2014/15 academic year only. Students continuing their studies into 2015/16 and beyond should not assume that this unit will be available in future years in the format displayed here for 2014/15.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.