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BB30162: Protein synthesis, folding and turnover

Follow this link for further information on academic years Academic Year: 2016/7
Further information on owning departmentsOwning Department/School: Department of Biology & Biochemistry
Further information on credits Credits: 6      [equivalent to 12 CATS credits]
Further information on notional study hours Notional Study Hours: 120
Further information on unit levels Level: Honours (FHEQ level 6)
Further information on teaching periods Period:
Semester 1
Further information on unit assessment Assessment Summary: CW 20%, EX 80%
Further information on unit assessment Assessment Detail:
  • Coursework (CW 20%)
  • Examination (EX 80%)
Further information on supplementary assessment Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this module you are advised to take BB20023
Further information on descriptions Description: Aims:
To introduce the process of transcription in prokaryotes.
To provide an understanding of ribosome structure and mRNA translation in both prokaryotes and eukaryotes.
To detail the process of protein folding and the intracellular pathways of folding and post-translational modification.
To explain the various pathways of intracellular and extracellular protein turnover.
To provide students with an integrated and comprehensive view of the key processes controlling the production and turnover of cellular proteins.

Learning Outcomes:
After taking this course the student should be able to:
* describe and explain how bacterial gene expression is regulated at the transcriptional level;
* describe and explain the process of translation;
* explain and critically evaluate our current understanding of the processes involved in protein folding;
* describe the pathways and explain the importance of protein turnover;
* analyse the strengths and limitations for current predictive methods for protein structure.

Skills:
Learning and studying T/FA, Written communication T/FA, Information handling & retrieval T/FA, Working independently T/F, Information technology T/FA.

Content:
Prokaryotic transcription (5 lectures).
Translation (5 lectures).
Protein Folding (4 lectures).
Posttranslational modification (3 lectures).
Protein Turnover (3 lectures).
Computational approaches to the prediction of protein folding (practical) (16 hr).
Further information on programme availabilityProgramme availability:

BB30162 is Compulsory on the following programmes:

Department of Biology & Biochemistry
  • USBB-AFB02 : BSc(Hons) Biochemistry (Year 3)
  • USBB-AKB06 : BSc(Hons) Biochemistry with Professional Placement (Year 4)
  • USBB-AFB05 : BSc(Hons) Molecular and Cellular Biology (Year 3)
  • USBB-AKB08 : BSc(Hons) Molecular and Cellular Biology with Professional Placement (Year 4)

BB30162 is Optional on the following programmes:

Programmes in Natural Sciences
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Year 3)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences with Study year abroad (Year 4)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences with Year long work placement (Year 4)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Year 3)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences with Study year abroad (Year 4)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences with Professional Placement (Year 4)

Notes: