 Academic Year: | 2017/8 |
| Owning Department/School: | Department of Chemistry |
| Credits: | 3 [equivalent to 6 CATS credits] |
| Notional Study Hours: | 60 |
| Level: | Masters UG & PG (FHEQ level 7) |
| Period: |
- Semester 2
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| Assessment Summary: | EX 100% |
| Assessment Detail: | |
| Supplementary Assessment: |
- Like-for-like reassessment (where allowed by programme regulations)
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| Requisites: |
Before taking this module you must take CH20149 OR take CH20150
In taking this module you cannot take CH30068
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| Description:
| Aims:
To revise some basic concepts in physical organic chemistry and develop a number of ideas used to correlate reactivity and mechanism in a range of organic reactions.
Learning Outcomes:
After studying the Unit, students should be able to:
* Describe some experimental tools for investigating reaction mechanisms and the use of some theoretical models for their correlation and interpretation
* Suggest solutions for complex problems involving combinations of numerical and mechanistic information from a variety of sources.
* Propose appropriate experimental approaches for determination of organic reaction mechanisms.
Skills:
Problem solving (T, F, A), Scientific writing (F, A), Independent working (F).
Content:
Energy changes in equilibria and reactivity. Transition states and saddle points. Activation parameters. Analysis of reaction coordinates. Principle of Least Nuclear Motion. Hammond Postulate. More O'Ferrall - Jencks diagrams. Rate - equilibrium correlations. Hammett equation as an example of a linear free-energy relationship. Significance of s and rfor reactivity and mechanism. Complex Hammett plots: change in mechanism vs. change in rate-determining step. Equilibrium and kinetic isotope effects. Primary and secondary effects and their significance. Heavy-atom effects. Solvent isotope effects.
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| Programme availability: |
CH40068 is Optional on the following programmes:
Department of Chemistry
- TSCH-AFM04 : MSc Chemistry for Drug Discovery
- USCH-AAM03 : MChem(Hons) Chemistry with Study year abroad (Year 4)
- USCH-AAM06 : MChem(Hons) Chemistry for Drug Discovery with Study year abroad (Year 4)
- USCH-AKM03 : MChem(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 4)
- USCH-AKM02 : MChem(Hons) Chemistry with Industrial Placement (Year 4)
- USCH-AFM07 : MSci(Hons) Chemistry with Management (Year 4)
- USCH-AKM07 : MSci(Hons) Chemistry with Management with Industrial Placement (Year 5)
Programmes in Natural Sciences
- UXXX-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 4)
- UXXX-AAM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 5)
- UXXX-AKM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Professional Placement (Year 5)
- UXXX-AFM01 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) (Year 4)
- UXXX-AAM02 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Study year abroad (Year 5)
- UXXX-AKM02 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Professional Placement (Year 5)
- UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 4)
- UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 5)
- UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Professional Placement (Year 5)
- UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) (Year 4)
- UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Study year abroad (Year 5)
- UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Professional Placement (Year 5)
- UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 4)
- UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 5)
- UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Professional Placement (Year 5)
- UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) (Year 4)
- UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Study year abroad (Year 5)
- UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Professional Placement (Year 5)
- UXXX-AFM01 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) (Year 4)
- UXXX-AAM02 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Study year abroad (Year 5)
- UXXX-AKM02 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Professional Placement (Year 5)
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