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CE40130: Advanced bioprocessing in tissue engineering

[Page last updated: 15 October 2020]

Follow this link for further information on academic years Academic Year: 2020/1
Further information on owning departmentsOwning Department/School: Department of Chemical Engineering
Further information on credits Credits: 6      [equivalent to 12 CATS credits]
Further information on notional study hours Notional Study Hours: 120
Further information on unit levels Level: Masters UG & PG (FHEQ level 7)
Further information on teaching periods Period:
Semester 1
Further information on unit assessment Assessment Summary: EX 100%
Further information on unit assessment Assessment Detail:
  • Examination (EX 100%)
Further information on supplementary assessment Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites:
Description: Aims:
To develop students' ability to apply chemical engineering principles to design challenges in bioprocessing with a focus on tissue engineering applications.

Learning Outcomes:
On successful completion of this unit students should be able to:
* Select and explain biological conditions as relevant to tissue engineering applications,
* Critically evaluate biological data to inform the design of tissue engineering-based products,
* Identify and apply appropriate mathematical models to design and analyse tissue engineering systems,
* Propose and justify the design of tissue engineering tools, products or treatments, by inventing new- or adapting and modifying available designs.

Skills:
Acquisition of biological data and interdisciplinary technical information [T,F,A]
Critical assessment and selection of relevant biological data and interdisciplinary technical information [T,F,A]
Application of chemical engineering to bioprocess design challenges, applied to tissue engineering [T,F,A]
Team work [T,F].

Content:
This unit will study tissue engineering across the scales from the cell-biomaterial interface, to bioreactor design, to system design, with the goal of designing efficient tissue engineering systems.
This unit utilizes a combination of traditional lectures and group work sessions.

Review of basic human cell biology.
Shear stress effects on cell morphology, signal transduction and mass transfer. Control of cell function by the extracellular matrix and soluble growth factors (tissue microenvironments).
Scaffolds/substrates design and characterisation for tissue engineering, interaction of cells with artificial substrates.
Fluid mechanical effects on cellular function: devices and methodology used for in-vitro systems.
Stem cell engineering and scaffold/substrate effects.
Basic principles of cell adhesion, principles of cell migration.
Mathematical models for bioreactor design.
Bioreactor design for different tissue engineered products.
Further information on programme availabilityProgramme availability:

CE40130 is Compulsory on the following programmes:

Department of Chemical Engineering
  • UECE-AFM01 : MEng(Hons) Biochemical Engineering (Year 4)
  • UECE-AKM01 : MEng(Hons) Biochemical Engineering with Year long work placement (Year 5)

CE40130 is Optional on the following programmes:

Department of Chemical Engineering
  • UECE-AFM05 : MEng(Hons) Chemical Engineering (Year 4)
  • UECE-AKM05 : MEng(Hons) Chemical Engineering with Year long work placement (Year 5)

Notes:

  • This unit catalogue is applicable for the 2020/21 academic year only. Students continuing their studies into 2021/22 and beyond should not assume that this unit will be available in future years in the format displayed here for 2020/21.
  • Programmes and units are subject to change in accordance with normal University procedures.
  • Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.
  • Find out more about these and other important University terms and conditions here.