CH20177: Organic chemistry 4 for visiting students
[Page last updated: 15 October 2020]
Academic Year: | 2020/1 |
Owning Department/School: | Department of Chemistry |
Credits: | 6 [equivalent to 12 CATS credits] |
Notional Study Hours: | 120 |
Level: | Intermediate (FHEQ level 5) |
Period: |
- Semester 2
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Assessment Summary: | EX 100% |
Assessment Detail: | |
Supplementary Assessment: |
- Like-for-like reassessment (where allowed by programme regulations)
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Requisites: |
In taking this module you cannot take CH20149 AND take CH20150
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Description: | Aims: To provide the student with a working knowledge of important classes of organic transformations and illustrate how the rate and mechanism of a chemical reaction can be understood in terms of the chemical structure of molecules. To show how experimental kinetic data may be used to elucidate chemical reaction mechanisms.
Learning Outcomes: After studying this Unit, students should be able to:
* Describe the synthetic chemistry of carbocations, anions and radical species and describe some of the mechanisms involved in their reaction.
* analyse experimental rate data for first- and second-order reactions;
* describe how the involvement of a reaction intermediate may be deduced;
* discuss the stereochemistry of aliphatic nucleophilic substitution;
* describe the effects of added ions upon SN1 substitutions;
* discuss the role of ion pairs in unimolecular solvolyses;
* determine the pH of a buffer solution;
* describe the effect of pH on the rates of acid or base catalysed reactions;
* distinguish general catalysis from specific catalysis by acids or bases;
* describe the features of nucleophilic catalysis;
* rationalise the reactivity of molecules using stereoelectronic principles.
Skills: Problem solving (T, F, A), Data Analysis (T, F, A), Independent working (F), Group working (F).
Content: Aliphatic nucleophilic substitution: 1st & 2nd order kinetics, competing reactions; Deduction of reaction mechanism, evidence for intermediates; Stereochemical evidence for the SN2 mechanism; Evidence for the SN1 mechanism: consecutive reactions, common-ion effect, solvolysis, ion pairs; Acid/base catalysis: solvent levelling, buffers, specific & general catalysis; Nucleophilic catalysis.
Review of basic stereochemistry principles. The importance of stereoselective synthesis. Diastereomers and diastereoselective synthesis. Conformation of cyclohexanes - the importance of stereochemistry to reactivity - carbohydrates. Stereochemistry and mechanism. Frontier Molecular Orbital Theory and stereoelectronic effects. Aspects of the chemistry of carbocations, carbanions, radicals, carbenes, nitrenes, and arynes. |
Programme availability: |
CH20177 is only available to visiting/exchange students
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Notes: - This unit catalogue is applicable for the 2020/21 academic year only. Students continuing their studies into 2021/22 and beyond should not assume that this unit will be available in future years in the format displayed here for 2020/21.
- Programmes and units are subject to change in accordance with normal University procedures.
- Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.
- Find out more about these and other important University terms and conditions here.
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