SL20027: Pharmacokinetics (PA20294)
[Page last updated: 26 October 2023]
Academic Year: | 2023/24 |
Owning Department/School: | Department of Life Sciences |
Credits: | 3 [equivalent to 6 CATS credits] |
Notional Study Hours: | 60 |
Level: | Intermediate (FHEQ level 5) |
Period: |
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Assessment Summary: | EX 100%, OT 0% |
Assessment Detail: |
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Supplementary Assessment: |
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Requisites: | |
Learning Outcomes: |
By the end of the unit the student will be able to:
1. Describe the pre-clinical and clinical phases involved in drug development. 2. Explain and contrast the concepts of bioavailability, bioequivalence, generics, and orphan drugs. 3. Explain multiple dose pharmacokinetics and their application to dose regime design. Estimate Cmax, Cmin and Css. 4. Explain rate-limiting processes in pharmacokinetics. Interpret and illustrate flip-flop kinetics and metabolite kinetics. 5. Contrast linear and non-linear pharmacokinetics. Explain the clinical relevance of non-linear pharmacokinetics. 6. Explain distribution kinetics, two compartment models and their clinical relevance. 7. Formulate sources of variability in drug pharmacokinetics: age, disease, food and drug interactions, natural and herbal products. 8. Explain pharmacogenetics and their application to individualized medicine 9. Explain the process of drug therapeutic monitoring and its application in drug therapy. |
Aims: | To learn pharmacokinetics and its relevance in drug development and drug therapy. |
Skills: | 1. Data analysis
2. Problem solving. 3. Analytical thinking 4. Scientific skills 5. Handling information 6. Professional skills All taught and assessed. |
Content: | 1. The process of drug development. Pre-clinical and clinical studies. Pharmacovigilance. Generics and bioequivalence. Orphan drugs.
2. Multiple dose pharmacokinetics and design of a dosage regime. IV Bolus and Extravascular. Prediction of Cmax, Cmin and Css. 4. Rate-limiting processes in pharmacokinetics. Flip-flop kinetics. Metabolite kinetics. 5. Non-linear pharmacokinetics. Non-linearity in ADME processes. Michaelis-Menten kinetics. Clinical relevance of non-linear pharmacokinetics. 6. Distribution kinetics. Two compartment models and their clinical relevance. 7. Variability in drug pharmacokinetics: age, disease, food and drug interactions, natural and herbal products. 8. Pharmacogenetics and their application to individualized medicine 9. Drug therapeutic monitoring and its application in drug therapy. Case studies. |
Course availability: |
SL20027 is Compulsory on the following courses:Department of Life Sciences
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Notes:
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