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SL30075: Protein synthesis, folding and turnover (BB30162)

[Page last updated: 26 October 2023]

Academic Year: 2023/24
Owning Department/School: Department of Life Sciences
Credits: 6 [equivalent to 12 CATS credits]
Notional Study Hours: 120
Level: Honours (FHEQ level 6)
Period:
Semester 1
Assessment Summary: CW 30%, EX 70%
Assessment Detail:
  • BB30162 Coursework (CW 30%)
  • BB30162 Examination (EX 70%)
Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Requisites: Before taking this module you are advised to take BB20023 OR take SL20003
Learning Outcomes: After taking this course the student should be able to:
* describe and explain how bacterial gene expression is regulated at the transcriptional level;
* describe and explain the process of translation;
* explain and critically evaluate our current understanding of the processes involved in protein folding;
* describe the pathways and explain the importance of protein turnover;
* analyse the strengths and limitations for current predictive methods for protein structure.


Aims: To introduce the process of transcription in prokaryotes.
To provide an understanding of ribosome structure and mRNA translation in both prokaryotes and eukaryotes.
To detail the process of protein folding and the intracellular pathways of folding and post-translational modification.
To explain the various pathways of intracellular and extracellular protein turnover.
To provide students with an integrated and comprehensive view of the key processes controlling the production and turnover of cellular proteins.

Skills: Learning and studying T/FA, Written communication T/FA, Information handling & retrieval T/FA, Working independently T/F, Information technology T/FA.

Content: Prokaryotic transcription (5 lectures).
Translation (5 lectures).
Protein Folding (4 lectures).
Posttranslational modification (3 lectures).
Protein Turnover (3 lectures).
Computational approaches to the prediction of protein folding (practical) (16 hr).

Course availability:

SL30075 is Compulsory on the following courses:

Department of Chemistry
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Year long work placement (Year 4)
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) with Year long work placement (Year 4)
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Year long work placement (Year 4)
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Year long work placement (Year 4)
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) with Year long work placement (Year 4)
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Year long work placement (Year 4)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 4)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Professional Placement (Year 4)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 4)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Professional Placement (Year 4)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 4)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Professional Placement (Year 4)
Department of Life Sciences
  • USSL-AFB01 : BSc(Hons) Biochemistry (Year 3)
  • USSL-AKB01 : BSc(Hons) Biochemistry with Professional Placement (Year 4)
  • USSL-AFM01 : MBiochem(Hons) Biochemistry (Year 3)
  • USSL-AKM01 : MBiochem(Hons) Biochemistry with Professional Placement (Year 4)

SL30075 is Optional on the following courses:

Department of Chemistry
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Year long work placement (Year 4)
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) with Year long work placement (Year 4)
  • USSC-AFB01 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) (Year 3)
  • USSC-AAB01 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) with Study year abroad (Year 4)
  • USSC-AKB01 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) with Year long work placement (Year 4)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 3)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 4)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Professional Placement (Year 4)
Department of Life Sciences
  • USSL-AFB03 : BSc(Hons) Biomedical Sciences (Year 3)
  • USSL-AKB03 : BSc(Hons) Biomedical Sciences with Professional Placement (Year 4)
  • USSL-AFM03 : MBioMed(Hons) Biomedical Sciences (Year 3)
  • USSL-AKM03 : MBioMed(Hons) Biomedical Sciences with Professional Placement (Year 4)

Notes:

  • This unit catalogue is applicable for the 2023/24 academic year only. Students continuing their studies into 2024/25 and beyond should not assume that this unit will be available in future years in the format displayed here for 2023/24.
  • Courses and units are subject to change in accordance with normal University procedures.
  • Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.
  • Find out more about these and other important University terms and conditions here.