SL52131: Physiology, pathology and pharmacology
[Page last updated: 15 August 2024]
| Academic Year: | 2024/25 |
| Owning Department/School: | Department of Life Sciences |
| Credits: | 15 [equivalent to 30 CATS credits] |
| Notional Study Hours: | 300 |
| Level: | Masters UG & PG (FHEQ level 7) |
| Period: |
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| Assessment Summary: | CWRI 40%, EXOB 60% |
| Assessment Detail: |
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| Supplementary Assessment: |
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| Requisites: | While taking this module you must take SL52128 |
| Learning Outcomes: |
After studying this unit, students should be able to:
Illustrate the role of biological molecules in regulating cellular function and how these can function as drug targets.
Distinguish the concepts of drug affinity, potency and efficacy.
Explain the methodologies involved in genetic manipulation and appreciate the application of these techniques to drug discovery.
Describe the methodologies associated with the production of biological and immune-based therapies and their potential application.
Demonstrate knowledge of and competency in a range of key laboratory skills including those required for a research project in semester 3.
Demonstrate skills in planning and executing practicals to address problems using microbiological, molecular and pharmacological assays.
Generate, analyse and interpret data collected.
Present the results of an investigation in written reports.
Work in a team, allocating and correlating tasks and ensuring accurate collection of data.
Solve problems using the methods introduced including the application of techniques to unseen situations. |
| Synopsis: | You will develop core knowledge of cellular biology and signalling mechanisms for the identification of biological molecules as drugs and drug targets. You will develop the ability to apply this knowledge to carry out laboratory-based investigations. |
| Content: | Biological molecules as drugs and drug targets - Proteins - receptors, enzymes, antibodies.
Microbial proteins as drug targets.
Cloning and recombinant production of biopharmaceuticals, vector/plasmid delivery/gene therapies.
Receptor Pharmacology; agonist/antagonist; affinity/potency/efficacy.
Receptor signalling mechanisms.
Immunology - targets for inflammation particularly biological therapies/immunotherapy.
Practicals - to enable the students to develop knowledge of and competency in a range of experimental and data analysis techniques:
* Microbiology * Molecular analysis * Agonist and antagonist profiles on biological tissue * Radioligand binding |
| Course availability: |
SL52131 is Optional on the following courses:Department of Life Sciences
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Notes:
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